A deadly serum that causes anyone it touches to go violently insane has been stolen. Spider-Man must find a culprit before the serum is used to wreck havoc on the city. As if it wasn't enough someone has freed Carnage The Psychotic superpower serial killer from prison and he's done in for Spidey. But even those crises pill in comparison to the Revelation that is a rock and Spider-Man to the very Soul the return of the Green Goblin of those Spidey thought was dead twice over and the Goblin is determined to drive Spider-Man over the edge. Two deadly enemies brought together in a electrifying Adventure that could mean the end of The Amazing Spider-Man