The story is set in the small town of Gopher Prairie, a fictionalized version of Sauk Centre, Minnesota, Lewis's hometown, during the 1910s. It relates the life and struggles of Carol Milford Kennicott, a self-made young woman with a strong personality, as she comes into conflict with the small-town mentality of the residents of Gopher Prairie. References are made to the start of World War I, the United States' entry into the war, and the years following its end, including the start of Prohibition in 1920.